Verkerk/Wilders group – Cardiac Cellular Electrophysiology

The molecular and cellular mechanisms of cardiac pacemaking and arrhythmias are studied during development, aging and disease using sophisticated and novel techniques for ion channel function studies (e.g. patch clamp, action potential clamp, and dynamic action potential clamp), mathematical cell models, and various transgenic mouse and human induced pluripotent stem cell derived cardiomyocyte (hiPSC-CMs) models.

Contact: A.O. Verkerk (

Research overview

Dr. Arie O. Verkerk, Dr. Ronald Wilders, and group members, have worked on basic mechanisms of cardiac electrical activity, excitation-contraction coupling, arrhythmias, and heart failure, with particular emphasis on ion channels, ion exchangers and impulse propagation. See ‘Publications’ for a complete overview of topics. Specifically, the expertise of the group members covers a wide range of the functional aspects of the various cardiac cell types (sinoatrial node, atrial, atrioventricular node, Purkinje, and ventricular myocytes) and constitutes the link between ‘clone’ (molecular biology, proteomics, genetics, cardiac embryology) and ‘clinic’. Accordingly, research is conducted in close collaboration with basic scientists on one hand and clinicians on the other hand.


Arie Verkerk (
Ronald Wilders (
Antoni van Ginneken (
Berend de Jonge (


For publications by this research group, click here.